Top Mississippi River Cruise Experiences You Must Try

July. 16,2025

Discover the top Mississippi River cruises offering scenic views, cultural insights, and luxurious amenities. From quick day trips to extensive 22-day journeys, explore popular routes, elegant ships, and engaging excursions perfect for a memorable river adventure.

Top Mississippi River Cruise Experiences You Must Try

Top Mississippi River Cruise Experiences You Must Try

Escape everyday stress by exploring the Mississippi River on a scenic cruise. Numerous reputable cruise lines operate along this iconic waterway, offering memorable journeys. Here are some of the most popular Mississippi River cruises to consider for your next vacation.

Twilight Riverboat
For a quick retreat, the Twilight Riverboat provides elegant short trips, including day and overnight options. Departing from Dubuque, the day cruise heads north to Guttenberg and returns by evening, offering breakfast, lunch, and snacks. The two-day tour from Le Claire to Dubuque features educational commentary on local history, wildlife, and scenery. Guests can also explore Dubuque’s museums and markets.

Mississippi River cruise experiences
This cruise includes meals and scenic views, ideal for quick getaways.

American Queen Steamboat
Known for its elegant design and modern amenities, the American Queen offers luxurious accommodations, gourmet dining, live entertainment, spas, and fitness centers. Expert guides onboard share insights into the cultural and historical significance of Mississippi River cities, enriching your journey. Cruises typically last from 5 to 9 days, with routes stopping at ports like Baton Rouge, Memphis, Natchez, Vicksburg, St. Louis, Nashville, and Helena.

Spirit of Peoria
The Spirit of Peoria provides versatile overnight cruises ranging from two to five days, perfect for a one-week vacation. Popular destinations include St. Louis, Starved Rock, and Hannibal. The cruises feature meals, live entertainment such as music and storytelling, and excursions in port cities. The company also offers themed, sightseeing, single-day, and private charter cruises.

American Cruise Lines
For those interested in an extended adventure, the Mississippi River Tour by American Cruise Lines covers ten states in 22 days. Starting in New Orleans and ending in St. Paul, this journey showcases a diverse array of American towns and cities, offering a deep dive into local history and culture. This is a once-in-a-lifetime experience to see the heart of America from the river.