Understanding the Main Causes of Low Sodium Levels in the Body

July. 16,2025

Hyponatremia, defined as low blood sodium, can result from medications, health conditions, excessive water intake, or hormonal imbalances. Recognizing the primary causes is vital for prevention and effective treatment. This article explores key factors contributing to low sodium levels, including drug effects, fluid retention issues, and hormonal disorders, offering valuable insights into managing or avoiding this condition.

Understanding the Main Causes of Low Sodium Levels in the Body

Major Factors Contributing to Hyponatremia

Hyponatremia occurs when blood sodium drops below 135 mEq/L, with normal levels ranging from 135 to 145 mEq/L. Sodium plays a vital role in controlling blood pressure, supporting nerve and muscle functions, and balancing body fluids. Various factors can lead to hyponatremia. Here are some key causes:

  • Medications and Drugs

Certain medications, including diuretics, antidepressants, and painkillers, may contribute to low sodium levels. These drugs can increase urination or sweating, reducing sodium concentration in your blood.

Major Causes of Hyponatremia
  • Heart, Liver, and Kidney Conditions

Fluid retention from conditions like heart failure or liver and kidney diseases can dilute sodium levels, leading to hyponatremia. Excess fluids accumulate in the body, lowering sodium concentration.

  • Syndrome of Inappropriate Antidiuretic Hormone (SIADH)

This condition involves abnormal production of ADH, causing the body to retain water and reduce sodium levels. Excess water retention is a significant contributor to hyponatremia.

  • Overhydration and Excess Water Intake

Engaging in vigorous physical activity causes sodium loss through sweating. Drinking large amounts of water during or after such activities can lead to a dilution of sodium, resulting in hyponatremia. Even excessive water intake in daily life can lower sodium levels.

  • Recreational Use of Ecstasy

Ecstasy can cause rapid fluid loss and increased sweating. The drug’s effects, including the release of amphetamine, heighten the risk of severe hyponatremia and potential life-threatening complications.

  • Hormonal Imbalances

Conditions like Addison’s disease impair adrenal hormone production, disrupting sodium, potassium, and water balance. Low thyroid hormone levels can also contribute to decreased blood sodium levels.