Top 6 Prescription Drugs for Managing Migraines
Explore six common prescription medications used to treat and prevent migraines. Learn how drugs like Ergomar, ONZETRA, Trokendi XR, BOTOX, Aimovig, and AJOVY work, their uses, and precautions. Consult your healthcare provider for personalized advice on migraine management and proper treatment options.

Top 6 Prescription Medications for Managing Migraines
Migraines are intense, recurring headaches often accompanied by sensory symptoms such as temporary vision loss, tingling sensations in limbs, speech difficulties, light sensitivity, and involuntary movements. They can last hours or days depending on severity.
According to the American Migraine Foundation, over 36 million people suffer from migraines, with women experiencing three times more than men. The exact cause is unknown, but triggers include hormonal changes, stress, fatigue, alcohol, caffeine, dehydration, certain medications, and environmental factors.
Treatment Options
These medications are commonly prescribed to relieve symptoms or prevent future attacks. Some treat ongoing migraines, while others reduce attack frequency:
Ergomar®
This ergot alkaloid is designated for migraine episodes by constricting dilated cranial blood vessels. It is effective during an attack but does not prevent migraines or decrease their occurrence.
ONZETRA® Xsail®
A nasal sumatriptan powder delivered with the Breath Powered® device, it targets serotonin receptors to constrict blood vessels and alleviate pain during acute migraines. It is not for prevention.
Trokendi XR®
An anticonvulsant called topiramate, Trokendi XR is used to prevent migraines in both adolescents and adults. It does not treat active headache episodes.
BOTOX®
Administered as injections, BOTOX® blocks pain signal chemicals, suitable for chronic migraine sufferers experiencing 15 or more headache days per month. A neurologist consultation is recommended before use.
Aimovig®
This monoclonal antibody inhibits CGRP, a protein linked to migraine pathogenesis, helping prevent attacks in adults.
AJOVY®
Another monoclonal antibody, it prevents migraines by blocking CGRP activity, reducing attack frequency.
Always consult a healthcare professional before starting any medication to ensure appropriate treatment and safety.