Top Four Medications Commonly Used to Manage Depression Symptoms

July. 16,2025

Discover four commonly prescribed medications for managing depression symptoms, including dosage options and discount opportunities through GoodRx Gold. Learn how these medicines work and enhance treatment plans for mental health improvements with accessible pricing. A comprehensive guide for patients seeking effective depression management options.

Top Four Medications Commonly Used to Manage Depression Symptoms

Top Four Medications Commonly Used to Manage Depression Symptoms

Depression is a complex mental health condition characterized by persistent sadness, loss of interest, and a range of emotional and physical challenges. It impacts feelings, thoughts, and behaviors, often leading to fatigue, irritability, and despair. Recovery often involves a combination of medications, therapy, and lifestyle adjustments. Medication plays a vital role, with doctors frequently prescribing antidepressants or antianxiety drugs to alleviate symptoms. Here are four widely used medications in depression treatment:

Zoloft (Sertraline)
Zoloft is a leading antidepressant that belongs to the SSRI class. It works by increasing serotonin levels in the brain, boosting mood and reducing anxiety. It’s also prescribed for panic attacks, OCD, PTSD, and PMDD. Patients can benefit from discounts through GoodRx Gold, saving up to 88% on 30 tablets of 50 mg sertraline. The brand version of Zoloft can also be purchased at a reduced price with membership.

Top Medications for Depression

Prozac (Fluoxetine)
Prozact is another prominent SSRI used for treating major depression, eating disorders, and related conditions. It influences brain neurotransmitters, helping manage anxiety, panic, and obsessive-compulsive symptoms. Both generic and brand versions are available, with discounts up to 86% through GoodRx Gold on 20mg capsules, and up to 21% off for the Prozac brand.

Trazodone
Trazodone, an affordable SSRI, primarily aids in improving mood, appetite, sleep, and reducing anxiety linked to depression. It is only available in generic form, with substantial savings through GoodRx Gold — up to 83% on 50 mg tablets. Prices vary based on dosage and pharmacy.

Wellbutrin XL (Bupropion XL)
Wellbutrin XL is especially effective for major depression and seasonal affective disorder. It’s sold under various brand names, with GoodRx offering significant discounts — up to 87% on 300 mg tablets. Other discounts are available for different dosages. GoodRx Gold provides access to savings at major pharmacies nationwide, including CVS, Target, Kroger, and more.