Top 4 Medications for Managing GERD Symptoms

July. 16,2025

This article reviews four effective medications for managing GERD symptoms, including Nexium, Prevacid, Prilosec, and Aciphex. It highlights their uses, benefits, and savings options through GoodRx. Proper treatment, combined with lifestyle changes, can alleviate GERD discomfort and prevent complications. Always consult a healthcare professional for personalized advice.

Top 4 Medications for Managing GERD Symptoms

Top 4 Medications for Managing GERD Symptoms

Gastroesophageal reflux disease (GERD) is a condition where stomach acids flow back into the esophagus, causing discomfort and potential complications. This reflux occurs due to weakened esophageal muscles, leading to symptoms like burning chest pain (heartburn), a sour taste, dry cough, swallowing issues, and asthma-like symptoms. GERD can affect people of all ages, including infants and children.

Left untreated, GERD may cause serious issues such as esophageal narrowing, ulcers, or precancerous changes. Besides lifestyle adjustments, medications play a key role in symptom management. Here are four commonly prescribed options:

  • Nexium (Esomeprazole)
  • Prevacid (Lansoprazole)
  • Prilosec (Omeprazole)
  • Aciphex (Rabeprazole)

Nexium (Esomeprazole)

This medication is used to treat GERD-related ulcers and esophageal inflammation, and also works against bacteria. Esomeprazole helps prevent ulcers from NSAID use and effectively reduces stomach acid production compared to other proton pump inhibitors. While retail prices average around $285, GoodRx shoppers can find it for as low as $12.21, with GoodRx Gold available at $10.61.

Prevacid (Lansoprazole)

Available as capsules, Lansoprazole treats GERD symptoms, heartburn, and gastric or duodenal ulcers by lowering stomach acid. The 30mg capsules are often discounted to about $10.36 with GoodRx, a 90% saving. The 15mg version costs around $15.49, with GoodRx Gold priced at $6.72.

Prilosec (Omeprazole)

This medication manages acid levels to alleviate GERD symptoms, available both over-the-counter and by prescription. Typically costing around $9.55 retail, GoodRx offers it for just $3.99 with Gold membership, making it an affordable option for many.

Aciphex (Rabeprazole)

Rabeprazole reduces excess stomach acid, preventing reflux and inflammation, and treating ulcers and Zollinger-Ellison Syndrome. The generic version is available for about $9.71 through GoodRx, compared to a retail price of roughly $142.80. Subscribers to GoodRx Gold can also access it for $5.99 per month.

Note:
The information presented aims to inform readers about treatment options for GERD. While insights are based on research, they should not replace professional medical advice. The website is not responsible for data inaccuracies or overlooked deals, and readers are encouraged to consult healthcare providers for personalized treatment plans.